The man often helps people( in )his work,这里的in能换成with吗?

The man often helps people( in )his work,这里的in能换成with吗?

i不能
in是在工作中
而with是除了工作中还有其实方面的,不仅指工作中帮助

The man often helps people( in )his work,这里的in能换成with吗？
可以。help sb with sth.
help sb (to) to sth